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]]ay:jyLvmodyÜH}} ADZajymif; udk½dkemAdkif;&yfpf tb,faMumifh ul;pufrIjrifhrm;&oenf;/
Date:2021-10-12    
    Alpha? Beta? Gamma rS Delta? Mu rsdK;ADZuGJAdkif;
&yfpfrsm;onf rqHk;cef;wdkif wpfckNyD; wpfckxGufay:
vmNyD; EdkifiHtoD;oD;\udkApf-19 a&m*gumuG,fxdef;
csKyfa&;tay: pOfqufrjywf pdefac:aeonf/ 4if;t
euf Delta Adkif;&yfpfonf vuf&SdurÇmhae&m tESHYtrsm;
tjym;ü ul;pufjyefYyGm;aeaom t"duul;pufjrefrsdK;
ADZajymif; Adkif;&yfpfjzpfonf/ ADZajymif;udk½dkemAdkif;&yfpf
tb,faMumifh ul;pufrIjrifhrm;&oenf;/ w½kwfEdkifiH
odyÜHokawoDrsm;onf rMumao;rDu tar&duefEdkifiH
]]Cell Report}} r*¾Zif;ü 4if;Adkif;&yfpf\ ]]vQdKU0Sufqef;
Mu,frI}}okawoejyKcsufwpf&yfudk azmfjycJhonf/
    yg;eyfvSaom udk½dkemAdkif;&yfpfonf ADZajymif;rsdK;
uGJopftjzpf ajymif;vJjzpfay:apEdkifonf/ tjynfjynf
qdkif&m rsdK;½dk;ADZqdkif&m t&if;tjrpfrQa0aom ]]wkwf
auG;a&m*gudef;*Pef; urÇmvHk;qdkif&m rQa0rI tqdkjyK
csuf}} yvufazmif;\ udef;*Pef;azmfjycsuft& 2021
ckESpf? Zefe0g&DvrSpwifí Alpha Adkif;&yfpfonf yxr
OD;qHk; ul;pufrItjrifhrm;qHk;jzpfcJhonf/ xdkYaemuf ar
vrSpwifí Delta Adkif;&yfpfonf wjznf;jznf;ESifhAlpha
Adkif;&yfpfudk tpm;xdk;vmcJhNyD; urÇmwpf0ef; t"duADZ
ajymif;rsdK;uGJAdkif;&yfpful;pufysHUESHUrIudk jzpfapcJhonf/
    okawoeawGU&Sdcsuft& Alpha Adkif;&yfpfESifhEIdif;
,SOfvQif Delta Adkif;&yfpf\ Spike Glycoprotein onf 
Leuko protease udk tvkyfvkyfEdkifaomy½dkwif;tjzpf 
zGJUpnf;&ef ydkrdkxda&mufpGmpkyf,lvufcHay;NyD; Delta Adkif;
&yfpfqJvf twGif;0ifa&mufaom xda&mufrIudk rsm;pGm
jr§ifhwifay;Edkifonf/ 4if;onf ul;pufrItapmydkif;um
vwGif Adkif;&yfpf  yGm;EIef;udkvnf;  ydkrdk jrefqefapum
Delta ADZajymif; Adkif;&yfpfjzpfaprIudk t"dutultnD
ay;aMumif; awGY&SdcJh&onf/
    ul;pufrI jrifhrm;onfhtjyif  ADZajymif;udk½dkemAdkif;
&yfpfonf ckcHtm;pepf xGufay:EdkifrIpGrf;&nf avsmhenf;
rIrSmvnf; ydkrdkjrifhwufvmcJhonf/ rlvudk½dkemAdkif;&yfpf
ESifhEIdif;,SOfvQif udkApfa&m*g aysmufuif;ol\Neutra-
lizing Antibody aoG;&nfMunfonf Delta Adkif;&yfpf\
Neutralizing pGrf;tm;udk rsm;pGmusqif;aponf/ um
uG,faq;ESifh ukoa&;wGiftoHk;jyKaom Monoclonal 
Antibody aq;rsm;onf Delta Adkif;&yfpf\ Neutra-
lizing udk odompGm usqif;apaMumif; awGY&SdcJhonf/
    Antibody-Mediated Humoral Immunity udk,f
cE¨m t&nfckcHtm;pepf xGufay:EdkifrIpGrf;&nf avsmh
enf;Edkifonfhtjyif Killer T-Cell mediated \ qJvf
ckcHtm;wkefYjyefrI   avsmhenf;rItay:wGifvnf;  ADZ
ajymif;udk½dkemAdkif;&yfpfonf tqufrjywfjyefYyGm;rIudk 
jr§ifhwifay;EdkifaMumif; csif;[Gmwuúodkvfaq;0g;ynm
aumvdyf Tan Xu "mwfcGJcef;ESifh w½kwfEdkifiHodyÜHenf;
ynm wuúodkvf Life Sciences ynmaumvdyf Jin 
Teng Chuan "mwfcGJcef;\aemufqHk;& okawoejyK
csufwGif awGU&SdcJhonf/ 
    qJvfckcHtm;onf vlYudk,fcE¨mtwGif; Antibody 
ckcHtm;jzpfonfhtjyif tjcm;ckcHtm; pepfwpfpHkvnf;
jzpfNyD; t"duvkyfaqmifcsufonf Killer T-Cell [kac:
aom aoG;jzLOrsm; a&m*gydk;ul;pufonfh vlYcE¨mukd,f
qJvfudk txl;cGJjcm;jcif;ESifhz,f&Sm;jcif;udk jyKvkyfay;
um xdkrSwpfqifh  Adkif;&yfpfyGm;rIESifh  ul;pufysHUESHYrIudk
wm;qD;ay;aom  ckcHpGrf;tm;  xda&mufrIudk &&Sdap&ef
jzpfonf/
    qJvfckcHtm;wkefYjyefrIESifh udkApfa&m*gtajctae
jyif;xefjcif;? rjyif;xefjcif;onf qufpyfaeaMumif;
udkvnf; okawoewpfcsdKUwGif azmfjyxm;onf/ ul;
pufcH&ol\aoG;&nfudk ppfaq;Munfh&mwGif udk½ddkem
Adkif;&yfpf txl;qJvfrsm;onf Neutralizing Antibody 
xufapmpD;pGmppfaq;awGU&Sdí qJvfckcHtm; wkefYjyefrI
onf a&m*gydk;ul;pufcH&onfh tapmydkif;umvwGif p
wifjzpfyGm;aeaMumif; azmfjyxm;onf/ tqdkygtapm
ydkif;umv\ ckcHtm;usqif;rIonf cE¨mukd,fpepfrS 
udk½ddkemAdkif;&yfpfudk ckcHumuG,f&ef? a&m*gydk;ul;pufysHUESHY
rIudk wm;qD;ESdrfESif;&eftwGufftvGefta&;BuD;onf/
    odkYaomf okawoDrsm;&SmazGawGY&SdonfrSm ADZajymif;
udk½dkemAdkif;&yfpf\ xl;jcm;aom,EÅ&m; wpfcsdKUonf 
4if;tm; qJvfckcHtm;xGufay:EdkifrIpGrf;&nf avsmhenf;
jcif;udk ulnDay;Edkifojzifh ul;pufrI xyfwpfqifh wdk;
jr§ifhrIudk jzpfapaMumif; awGU&SdcJhonf/ HTS (High-th
roughput Screening )enf;ynm yvufazmif;rSwpf
qifh okawoDrsm;onf udk½dkemAdkif;&yfpf\xl;jcm;csuf 
ESifhqJvfckcHtm;  ESifhqdkifaom  ta&;BuD;onfh Anti-
genic Epitope (4)aMumif;udk pdppfEdkifcJhNyD;? Alpha? Be-
ta? Gamma ESifh Delta Adkif;&yfpfonf tenf;qHk; ta&;
BuD;onfh Antigenic Epitope wpfaMumif;odkY ½kwfw
&uf  ajymif;vJrI  tenf;qHk;jzpfapNyD;  a&m*gydk;rsm; 
Killer T-Cell \ckcHtm; cGJjcm;rIrS avsmhenf;jcif;udk ul
nDay;onf/ vlYcE¨mudk,f qJvfckcHtm;xGufay:EdkifrI
pGrf;&nfavsmhenf;jcif;onf udk½dkemAdkif;&yfpfrsdK;uGJ jyefY
yGm;rIudkjzpfapaom a,bk,svu©Pmrsm;yifjzpfonf/
    xdkYjyif okawoDrsm;onf rwlnDaom udk½dkemAdkif;
&yfpftwGif;&Sd rajymif;vJaom Antigenic Epitope udk
a&G;cs,fEdkifcJhNyD; tqdkygAntigenic Epitope \rajymif;
vJjcif;onf 4if;onf udk½dkemAdkif;&yfpftay: ta&;BuD;
onfhvkyfaqmifcsuf&SdaMumif;udk azmfjyaeonf/
    csif;[Gmwuúodkvf aq;0g;ynmaumvdyf 'kwd,
ygarmu© rpöwmxef&GDu ADZajymif;udk½dkemAdkif;&yfpf\
ckcHtm;pepfxGufay:rIpGrf;&nf; avsmhenf;jcif;onf 
urÇmwpf0ef; umuG,faq;xdk;ESHrI tpDtpOftwGuf 
½IyfaxG;rI rsm;pGmjrifhwufapNyD; tqdkygrajymif;vJaom
Antigenic Epitope onf rsdK;qufopf udk½dkemAdkif;&yfpf
urÇmvHk;qdkif&m toHk;jyKEdkifonfhumuG,faq;xkwfvkyf
rItwGuf oDtdk&DtajccHudk axmufyhHay;cJhaMumif;? urÇm
vHk;qdkif&m toHk;jyKEdkifonfumuG,faq;opfonf vlY
cE¨mudk,frS Neutralizing Antibody xGuf&SdrIudk vIYHaqmf
ay;Edkifonfomru us,fjyefYaom qJvfckcHtm; wkefY
jyefrIudkvnf; yHkazmfay;EdkifNyD; ADZajymif;Adkif;&yfpf ul;
pufrItEÅ&m,f(umuG,faq;xdk;ESHNyD;aemuf jzpfyGm;
aomul;pufrI)usqif;rIudkvnf; jzpfapaMumif; ajym
Mum;cJhygonf/                     (qif[Gmowif;)